Natural killer cells receptor expression in endometriosis

Natural killer cells receptor expression in endometriosis By Yu Yu

Increasingly, studies have reported that endometriosis pathogenesis is related to defect in immune functions. The data also points to the impaired function of natural killer (NK) cells, leading to less cytotoxic NK cell activity in endometriosis. Similar to B and…

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Melatonin receptors and their role in endometrial cell proliferation

Melatonin receptors and their role in endometrial cell proliferation  By Hale Goksever Celik

Women with endometriosis demand therapy for the most common symptoms, which are pelvic pain and infertility. Despite extensive research, the exact pathophysiological mechanism and the optimal management of endometriosis still remains unclear. Management of endometriosis should aim to relieve pain,…

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How to Classify Endometriosis for a better and effective evaluation

How to Classify Endometriosis for a better and effective evaluation By Selma Oransay

Endometriosis affects 10% of women in their reproductive period and causes infertility around 40% of women who have the disease. Peritoneal fluid may be one of the factors to facilitate the spread of endometriosis to ovaries, peritoneum and other deep…

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New findings in adenomyosis (endometriosis interna) patients with potential theraupetic research implications

New findings in adenomyosis (endometriosis interna) patients with potential theraupetic research implications By Engin Aydin

Xue Shen and associates from Beijing, China have published their observations related to cannabinoid receptors, i.e., CB1 and CB2, in patients with adenomyosis, recently in the journal  "Biomed Research International".  Adenomyosis is an estrogen-dependent uterine disorder where a nonmalignant invasion…

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A new hope for a "targeted" drug for endometriosis

A new hope for a By Selma Oransay

Lin et al. from National Cheng Kung University, Taiwan, recently published in"Theranostics" the article entitled "Targeting Anthrax Toxin Receptor 2 Ameliorates Endometriosis Progression”,  report that ANTRX2 may be a novel therapeutic target for endometriosis. Thinking that the adhesion should be the first and the…

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Endometriosis and nuclear receptors

Endometriosis and nuclear receptors By Dr. Youngran Park

It is well recognized that endometriosis is a steroid-dependent disorder. In endometrial stromal cells, progesterone regulates retinoic acid production and action. Retinoids also act via a number of nuclear receptors (NRs) and are involved in normal endometrial function and endometriosis. Estrogen…

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Can we prevent the progression of endometriosis?

Can we prevent the progression of endometriosis? By Selma Oransay

Torres-Reveron et al. from the University of Texas, USA, planned this prospective laboratory research on female rats to assay the reduce on the progression of endometriosis and recently published the results in PloS One. At first,  endometriosis was induced in female rats…

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Growth Hormone-Inhibiting Hormone: Somatostatin and its receptors in endometriosis

Growth Hormone-Inhibiting Hormone: Somatostatin and its receptors in endometriosis By Engin Aydin

Yanhua Zhao and colleagues, led by Dr.Zhang from Hunan, China reported their recent research at Experimental and Therapeutic Medicine.  Somatostatin is a natural polypeptide extensively distributed in the digestive and nervous system, exhibiting several biological effects with a restricted clinical…

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Will my Endometriosis Respond to Hormone Therapy?

Will my Endometriosis Respond to Hormone Therapy? By Özge Özkaya

Every woman has a different set of hormone receptors in the lining of their uterus. Yet, hormone-based therapies that are used to treat women with endometriosis do not take into consideration these differences among patients. Analyzing, which particular hormone receptors…

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The Role of Natural Killer Cells in the Development of Endometriosis Unravelled

The Role of Natural Killer Cells in the Development of Endometriosis Unravelled By Özge Özkaya

Specialized immune cells called natural killer cells found in the peritoneal fluid of women with severe endometriosis may facilitate the development of the disease, according to a study published in the American Journal of Reproductive Immunology.   This finding could help…

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Endometriosis Does Not Increase Overall Risk of Breast Cancer, Study Finds

Endometriosis Does Not Increase Overall Risk of Breast Cancer, Study Finds By Özge Özkaya

Endometriosis is not associated with the overall risk of breast cancer, according to a study published in the journal Obstetrics & Gynecology.  The condition may, however, be significantly associated with an increased risk of breast tumors that express estrogen receptors (ER)…

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