Epigenetic link between endometriosis and cancer

Epigenetic link between endometriosis and cancer By Engin Aydin

Although endometriosis is considered a benign condition the cellular, histologic, and molecular data strongly demonstrate that endometriosis has neoplastic characteristics. There is strong evidence that endometriosis shares striking features with malignancy like normal tissue dissemination, invasion, and organ damage, as well as new vessel formation (neoangiogenesis).  In…

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Endometriosis From an Epigenetic Lens

Endometriosis From an Epigenetic Lens By Kasthuri Nair

Samadieh et al. from the Royan Institute for Reproductive Biomedicine, recently published an article in Reproductive Sciences titled “Epigenetic Dynamics of HOXA10 Gene in Infertile Women With Endometriosis.” In this paper, the researchers wanted to observe HOXA10 gene expression in…

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Epigenetic regulation of the pathological process in endometriosis.

Epigenetic regulation of the pathological process in endometriosis. By Dr. Youngran Park

Epigenetic mechanisms have been recognized as important players in the development of a broad range of human diseases including endometriosis. A growing body of evidence shows that the remodeling of retrograde endometrial tissues to the ectopic endometriotic lesions involves multiple epigenetic…

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Updates in the Field of Endometriosis: Epigenetics

Updates in the Field of Endometriosis: Epigenetics By Kasthuri Nair

In this chapter titled “A Review of the Epigenetic Contributions to Endometriosis,” Grimstad and Decherney examine various epigenetic influences that drive endometriosis disease progression. The epigenetic alterations they discuss include DNA methylation, histone modification, chromatin architecture changes, nuclear receptor modulation,…

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How ERα is regulated in endometriosis?

How ERα is regulated in endometriosis? By Yu Yu

Endometriosis pathogenesis is largely influenced by estrogen. Ectopic endometrium has altered expression of ERα compared to the eutopic endometrium. It is unclear what biological processes regulate such alteration. The article by Toderow et al. in Archives of Gynecology and Obstetrics…

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