By Ayse AyhanMacrophages Become Myofibroblasts in Endometriosis Fibrosis
By Ayse Ayhan
Fibrosis is a major but often underrecognized feature of endometriosis. It contributes to pain, adhesions, impaired endometrial receptivity, and progressive lesion stiffness. Although fibrosis is well documented in both ectopic lesions and the eutopic endometrium, the exact cellular mechanisms driving…
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By Selma OransayMolecular and cellular mechanisms of fibrogenesis in endometriosis
By Selma Oransay
Endometriosis lesions are characterized by endometrium-like cell proliferation, invasion, and oxidative stress associated with inflammation and neoangiogenesis. Fibrosis, which occurs due to these events, causes chronic pelvic pain depending on the location and the severity of endometriosis. For the purpose…
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By Özge ÖzkayaNew Signaling Pathway Could Be Crucial in the Development of Endometriosis
By Özge Özkaya
RAMP1 signaling is crucial for growth and blood and lymphatic vessel formation in endometrial tissue, according to a new study published in the Journal of Cellular and Molecular Medicine. This suggests that blocking RAMP1 could be a new way to…
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By Kasthuri NairMenstrual Effluent Can Change the Future of Endometriosis
By Kasthuri Nair
During Endometriosis Awareness Month, Warren et al. published a paper entitled “Analysis of menstrual effluent: diagnostic potential for endometriosis” in Molecular Medicine. This paper relies heavily on the theory of retrograde menstruation, where menstrual effluent flows into the peritoneal cavity.…
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By Dr. Youngran ParkEndometriosis and its pro-fibrotic nature.
By Dr. Youngran Park
Endometriosis is currently defined as the presence of endometrial epithelial and stromal cells at ectopic sites. However, with advances in disease knowledge, several vital issues challenge this old definition. Especially, endometrial stromal and glands have been shown to represent only…
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