What happens to women with endometriosis after menopause?

What happens to women with endometriosis after menopause? By Selma Oransay

Endometriosis affects women in their reproductive period of life, with expected regression of lesions in the postmenopausal period. Literature about postmenopausal endometriosis assessing the prevalence, pathogenesis, and treatment is limited. As 2-5 % of postmenopausal women are affected by this uncommon condition, developing stress…

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Seven Hormonal Biomarkers for Diagnosing Endometriosis

Seven Hormonal Biomarkers for Diagnosing Endometriosis By Dr. Youngran Park

Endometriosis is an inflammatory condition characterized by implantation and invasive growth of endometrial tissue outside the uterine cavity. Although it is benign, endometriosis has cancer-like features, a mutation profile similar to that of ovarian cancer, and increased ovarian cancer risk.…

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Novel inhibitors of estrogen biosynthesis

Novel inhibitors of estrogen biosynthesis By Dr. Youngran Park

Endometriosis is a chronic benign disease which is estrogen-dependent. Estradiol creates a positive feedback loop with the synthesis of pro-inflammatory mediators, which sustains further disease establishment and causes the pain symptoms. However, hormone therapies do not cure definitively endometriosis, because…

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Endometriosis and female pelvic pain in all aspects

Endometriosis and female pelvic pain in all aspects By Hale Goksever Celik

Endometriosis is defined as the localization of endometrial glandular and stromal tissue outside the uterine cavity. The prevalence of the disease ranges between 6-10% in reproductive-aged women. However, endometriosis is more frequently encountered in women with chronic pelvic pain and…

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Drugs targeting estrogen biosynthesis opening up new approaches to the treatment of endometriosis.

Drugs targeting estrogen biosynthesis opening up new approaches to the treatment of endometriosis. By Selma Oransay

Gibson et al., from the Univerity of Edinburgh, UK, take over a new interest about endometriosis occurrence and progress by endometrial tissue intracrinology in their recently online published article in International Journal of Molecular Sciences. The authors summarize the last…

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A clearer picture of "endometriosis after menopause"

A clearer picture of By Irem Onur

Delfin Avendano Tan and Marie Josephine Guanlao Almeria are obstetrician-gynecologists from the Philippines. They recently published a review article titled "Postmenopausal endometriosis: drawing a clearer picture". In this paper, the authors discussed the pathogenesis, risk factors, and management of postmenopausal…

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Investigational Medical Therapies for Endometriosis: Current Data and Future Trends. 

Investigational Medical Therapies for Endometriosis: Current Data and Future Trends.  By Dr. Youngran Park

The medical treatment of endometriosis has traditionally relied on hormonal therapies. Because these hormonal therapies preclude fertility or may have unwanted side effects, there is a great need for novel hormonal and non-hormonal medical options. Therefore, this review focuses on…

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Updates in the Field of Endometriosis: Epigenetics

Updates in the Field of Endometriosis: Epigenetics By Kasthuri Nair

In this chapter titled “A Review of the Epigenetic Contributions to Endometriosis,” Grimstad and Decherney examine various epigenetic influences that drive endometriosis disease progression. The epigenetic alterations they discuss include DNA methylation, histone modification, chromatin architecture changes, nuclear receptor modulation,…

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