Heme impairs macrophage phagocytosis

Heme impairs macrophage phagocytosis By Yu Yu

Heme is an iron-containing molecule that carries oxygen in the blood and also serves many essential biological proteins. It is released from ruptured erythrocytes during hemolysis. If not chelated, heme can cause harmful oxidative damage and inflammation. Thus, heme is…

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Control on endometriosis progression by a "tyrosine kinase inhibitor"

Control on endometriosis progression by a By Irem Onur

B cells, which are important players of the immune system, are increased in the blood and peritoneal cavity of endometriosis patients. Activation of B cells and the presence of anti-endometrial autoantibodies have been also been described in women with endometriosis,…

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Correlation between Treg cells and peritoneal lesions in women with ovarian endometrioma

Correlation between Treg cells and peritoneal lesions in women with ovarian endometrioma By Yu Yu

It is increasingly suggested that defective immune response is responsible for the survival and development of ectopic endometrial cells into endometriosis. In women with endometriosis, the immune system fails to create an inflammatory process that destroys endometrial cells at the…

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A newly found relationship between estrogen signalling and immune dysregulation in endometriosis

A newly found relationship between estrogen signalling and immune dysregulation in endometriosis By Yu Yu

It is believed that endometriosis progression is "at least partly" due to dysregulation of immune cells resulting in the poor clearance of ectopic endometrial debris. In particular, aberrant macrophage function was found to be important in the establishment of endometriosis, since…

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Anti-inflammatory cytokines: a new horizon in endometriosis with possible clinical relevance

Anti-inflammatory cytokines: a new horizon in endometriosis with possible clinical relevance By Engin Aydin

Scientists led by Dr. Li from Shangai PRC, have made a comprehensive review of anti-inflammatory cytokines related to the pathogenesis of endometriosis in a recent issue of Cellular and Molecular Life Sciences.    Inflammation is important in the pathogenesis of endometriosis,…

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Local inflammation and disease severity in endometriosis

Local inflammation and disease severity in endometriosis   By Yu Yu

During inflammation, immune cell receptors recognize endogenous molecules called danger-associated molecular patterns (DAMPs) or ‘alarmins’. This process reflects tissue damage and is mediated upon cell death in the condition of strong inflammation. HMGB1 and IL-33 are important DAMP molecules. Recently,…

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Immune dysregulation in endometriosis

Immune dysregulation in endometriosis By Yu Yu

The connection between endometriosis and the immune system has long been proposed. However, to date, there is no real consensus on whether immune adaptations actually facilitate endometriotric lesion progression or they are a consequence of endometriosis re-occurrence. Thus, this article…

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Another Study Suggesting That Endometriosis May Be a Disease Associated With Immune System Dysfunction

Another Study Suggesting That Endometriosis May Be a Disease Associated With Immune System Dysfunction By Özge Özkaya

An immune system protein called TGF-β in the peritoneal fluid or fluid that lubricates the lining of the abdominal wall and pelvic cavity may be creating an environment favorable for the formation of endometrial lesions. This is according to a…

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Altered Immunity in Endometriosis

Altered Immunity in Endometriosis By Yu Yu

In recent years, there has been increased attention on the role of immune system in endometriosis development. Normally, immune reactions are supposed to destroy endometrial cells seeding in the peritoneal cavity. Nonetheless, in endometriosis, these cells are able to evade,…

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Endocrine and inflammatory factors in current understanding of endometriosis

Endocrine and inflammatory factors in current understanding of endometriosis By Yu Yu

There are three forms of endometriosis: peritoneal, ovarian, and deep infiltrating. All three forms consist of endometriotic lesions containing endometrial glands, stroma, nerves, blood vessels, and inflammatory cells. Endometriosis symptoms can be accounted by these elements and the involving organs.…

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EFA Medical Conference 2017: "Cells Are the New Cure" Presentation by Dr. Max Gomez

EFA Medical Conference 2017: By Kasthuri Nair

Dr. Max Gomez is an award-winning broadcast journalist, CBS News Medical Correspondent, and a presenter at the EFA 2017 Medical Conference. Dr. Gomez’s presentation was titled “Cells Are the New Cure: The Cutting-Edge Medical Breakthroughs That Are Transforming Our Health.”…

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The role of the B lymphocytes in endometriosis: A systematic review

The role of the B lymphocytes in endometriosis: A systematic review By Murat Osman

Insight into the role of an inflammatory response in endometriosis has sparked further study into the role of different immune cells and their causal relationship to the pathogenesis of endometriosis. Several recent studies have found an association between aberrant immune…

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