A new "nonhormonal" treatment target in endometriosis

A new By Eylül GÜN

Endometriosis is a chronic inflammatory condition that affects millions of women globally. With pelvic pain being its most common symptom, the cost of the treatment of disease-associated symptoms has been found to be almost as high as type 2 diabetes.…

Key Points Lay Summary

Hormone Control Related Genes in Women With Endometriosis

Hormone Control Related Genes in Women With Endometriosis By Ellen Tumimbang

Endometriosis is an estrogen-dependent disease.  The development of endometriosis is stimulated by the specific ability to receive the estrogen that is needed for growth and differentiation of endometrial cells and has numerous biological functions in eutopic and ectopic endometrium. Estrogen…

Key Points Lay Summary

Autophagy, proteolysis and Endometriosis

Autophagy, proteolysis and Endometriosis By Kasthuri Nair

Sui et al., a group of researchers from the Qiqihar Medical University and Qilu Hospital of Shandong University, recently published in Experimental and Therapeutic Medicine. The piece titled “Expression and significance of autophagy genes LC3, Beclin1 and MMP-2 in endometriosis”…

Key Points Lay Summary

PROPOFOL: a new combat for endometriosis?

PROPOFOL: a new combat for endometriosis? By Selma Oransay

Feng et al, from the Department of  Gynecology Weifang Medical University Hospital, Shandong, China, recently published their prospective experimental research in the journal Experimental and Therapeutic Medicine. Propofol, a rapid and short-term anesthetic substance, recently has been shown to prevent cancer through inhibiting…

Key Points Lay Summary

BRAF: A Key Suspect in the Endometriosis Mystery

BRAF: A Key Suspect in the Endometriosis Mystery By Kasthuri Nair

LV et al., a group of researchers from China, recently published a study titled “Analysis of the oncogene BRAF mutation and the correlation of the expression of wild-type BRAF and CREB1 in endometriosis” in the International Journal of Molecular Medicine.…

Key Points Lay Summary

Molecular Susceptibility to Endometriosis

Molecular Susceptibility to Endometriosis By Kasthuri Nair

Fayez et al., a group of researchers from various institutions in Iran, recently published a paper in the Avicenna Journal of Medical Biotechnology titled “Arylamine N-acetyltransferase 2 Polymorphisms and the Risk of Endometriosis.” This study focused on the relationship between…

Key Points Lay Summary

CARD10 and CARD11 Mutations: Another Piece of the Puzzle

CARD10 and CARD11 Mutations: Another Piece of the Puzzle By Kasthuri Nair

Zou et al., a research group from China, recently published a study titled “Analysis of CARD10 and CARD11 somatic mutations in patients with ovarian endometriosis” in Oncology Letters. The paper looked at the effects of caspase recruitment domain family member…

Key Points Lay Summary

Polymorphism of IL12B May Help Solve Endometriosis

Polymorphism of IL12B May Help Solve Endometriosis By Kasthuri Nair

Zhao et al. recently published a paper titled “A functional promoter polymorphism in interleukin 12B gene is associated with an increased risk of ovarian endometriosis” in Gene. The research group from Hebei Medical University wanted to explore the potential roles…

Key Points Lay Summary

Menstrual Effluent Can Change the Future of Endometriosis

Menstrual Effluent Can Change the Future of Endometriosis By Kasthuri Nair

During Endometriosis Awareness Month, Warren et al. published a paper entitled “Analysis of menstrual effluent: diagnostic potential for endometriosis” in Molecular Medicine. This paper relies heavily on the theory of retrograde menstruation, where menstrual effluent flows into the peritoneal cavity.…

Key Points Lay Summary

The Potential Molecular Mechanisms that Drive Endometriosis Progression

The Potential Molecular Mechanisms that Drive Endometriosis Progression By Kasthuri Nair

Endometriosis is a mysterious disease in that the exact mechanism that causes the illness is still at large. Yang et al. recently published a paper in the European Review for Medical and Pharmacological Sciences that hopes to elucidate the molecular…

Key Points Lay Summary