DNA repair defects and Endometriosis

DNA repair defects and Endometriosis By Dr. Youngran Park

Endometriosis is a hormone-dependent disorder and highly associated with inflammation. It is well suggested that endometriosis increases the risks of developing cancers such as ovarian, breast, endocrine, and colorectal cancers. Compared to cancer, there are many similarities in endometriosis. Well-known characteristics…

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Oxidative Stress and Endometriosis

Oxidative Stress and Endometriosis By Murat Osman

Endometriosis is a disease characterized by ectopic endometrial tissue outside the endometrium and is associated with a background of a chronic inflammation. Recent studies have aimed to elucidate the inflammatory mediators involved in endometriotic lesions by studying immune cell interactions,…

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Endometrial stem cells and Endometriosis

Endometrial stem cells and Endometriosis By Dr. Youngran Park

Human endometrium is a cyclically proliferative tissue, and this monthly regeneration is likely mediated by endometrial stem (or progenitor) cells.The upper functional layer of the endometrium breaks down and is shed into the uterine cavity during menstruation. Re-epithelialization and repair…

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O6-Methylguanine-DNA Methyltransferase Plays a Role in Endometriosis Development

O6-Methylguanine-DNA Methyltransferase Plays a Role in Endometriosis Development By Kasthuri Nair

Shchegolev et al. recently published a paper in Bulletin of Experimental Biology and Medicine that explores the localization and behavior of O6-methylguanine-DNA methyltransferase, otherwise known as MGMT, a protein that repairs DNA and could potentially possess therapeutic properties. Their paper…

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