By Ayse AyhanMacrophages Become Myofibroblasts in Endometriosis Fibrosis
By Ayse Ayhan
Fibrosis is a major but often underrecognized feature of endometriosis. It contributes to pain, adhesions, impaired endometrial receptivity, and progressive lesion stiffness. Although fibrosis is well documented in both ectopic lesions and the eutopic endometrium, the exact cellular mechanisms driving…
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By Selma OransayMolecular and cellular mechanisms of fibrogenesis in endometriosis
By Selma Oransay
Endometriosis lesions are characterized by endometrium-like cell proliferation, invasion, and oxidative stress associated with inflammation and neoangiogenesis. Fibrosis, which occurs due to these events, causes chronic pelvic pain depending on the location and the severity of endometriosis. For the purpose…
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By Dr. Youngran ParkEndometriosis and its pro-fibrotic nature.
By Dr. Youngran Park
Endometriosis is currently defined as the presence of endometrial epithelial and stromal cells at ectopic sites. However, with advances in disease knowledge, several vital issues challenge this old definition. Especially, endometrial stromal and glands have been shown to represent only…
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