Early Developmental Gene May Play a Role in Endometriosis

Early Developmental Gene May Play a Role in Endometriosis By Özge Özkaya

An early developmental gene called twist may encourage the connective tissue cells of the lining of the uterus to change from being epithelial to being mesenchymal, so-called epithelial to mesenchymal transition (EMT).  Mesenchymal cells play important roles in biological processes…

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Conservative Surgery May Be Sufficient to Halt the Development of Deep Endometriosis

Conservative Surgery May Be Sufficient to Halt the Development of Deep Endometriosis By Özge Özkaya

Deep endometriosis develops as a result of collective cell migration and nerve recruitment from surrounding organs, suggests a study published in the scientific journal Fertility and Sterility.   Collective cell migration is the biological process whereby a group of cells moves…

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Programmed cell death 4 suppresses endometriosis by inhibiting autophagy and NF-κB/MMP2/MMP9 signal pathway

Programmed cell death 4 suppresses endometriosis by inhibiting autophagy and NF-κB/MMP2/MMP9 signal pathway By Dr. Youngran Park

Endometriosis is a kind of benign disease but shares many similar features with cancers, such as abnormal cell migration, invasion, and unrestrained growth. It has been known that some genes are expressed differentially in eutopic endometrium of EM patients compared…

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A Balancing Act: How Endometriosis Invades the Body

A Balancing Act: How Endometriosis Invades the Body By Murat Osman

Endometriosis is a disease defined by the presence of endometrial tissue outside of the uterine cavity. Ectopic endometrial tissues have been shown to have some features that mimic malignancy. For example, endometriosis can invade surrounding structures and attach to surfaces such…

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3,6-DHF suppresses the invasive properties of endometrial stromal cells through the Notch signaling

3,6-DHF suppresses the invasive properties of endometrial stromal cells through the Notch signaling By Dr. Youngran Park

Dr. Zhou group reported recently that 3,6-DHF can inhibit the development of EMT, migration, and invasion of endometrial stromal cells by inhibiting the Notch signaling pathway. Endometriosis is a condition in which the layer of tissue (glands and mesenchyme) that normally…

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Could the Sleep Hormone Treat Endometriosis?

Could the Sleep Hormone Treat Endometriosis? By Özge Özkaya

Melatonin blocks cell proliferation, invasion, and migration in both normal and endometriotic epithelial cells, according to a study published in the scientific journal Reproductive Biology and Endocrinology. Melatonin could, therefore, be a potential treatment for endometriosis  The formation and progression…

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Endometriosis Development: Pathogenesis and genomics

Endometriosis Development: Pathogenesis and genomics By Selma Oransay

In this review recently published in the International Journal of Molecular Sciences, Baranow et al from Saint Petersburg, Russia,  hypothesize the existence of an endometriosis development genetic program (EMDP) that governs the origin of endometrium stem cells programmed for endometriosis; their transition…

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Ping-Chong-Jiang-Ni Formula: A Natural Treatment

Ping-Chong-Jiang-Ni Formula: A Natural Treatment By Kasthuri Nair

In the world of modern medicine, natural and herbal remedies are often under utilized. Liang et al. recently published an article in Evidence-Based Complementary and Alternative Medicine where they explored the benefits of using a Chinese Herbal Medicine to treat…

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