How Epithelial-to-Mesenchymal Transition Alters Estradiol Metabolism in Endometriotic Cells?

How Epithelial-to-Mesenchymal Transition  Alters Estradiol Metabolism in Endometriotic Cells? By Selma Oransay

Researchers are increasingly uncovering how endometriosis behaves not just as a hormonal disorder but as a condition shaped by complex cellular signaling pathways. A new study published in Biochemical and Biophysical Research Communications helps explain why endometriotic lesions are able…

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Endometriosis as a Cardiovascular Risk Factor: A Comprehensive Meta-Analytic Review

Endometriosis as a Cardiovascular Risk Factor: A Comprehensive Meta-Analytic Review By Selma Oransay

Cardiovascular disease is the leading cause of death among women worldwide, accounting for nearly one-third of all deaths. While traditional risk factors include smoking and diabetes, women also face sex-specific contributors such as polycystic ovary syndrome, hypertensive disorders of pregnancy,…

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What are the most common symptoms of endometriosis and how are they related to age?

What are the most common symptoms of endometriosis and how are they related to age? By Eylül GÜN

Even though the incidence of endometriosis is relatively high and numerous studies are being conducted to elucidate its pathogenesis, it is still a highly underdiagnosed and undertreated disease. The symptoms of the disease are well-known; however, the correlation between the…

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Does ovarian endometriosis affect oocyte quality?

Does ovarian endometriosis affect oocyte quality? By Dr. Youngran Park

Endometriosis is a very common gynecological disorder affecting women in their reproductive years. It is reported that patients with endometriosis have reduced implantation and pregnancy rates compared to healthy women. According to the various previous studies, the quality of the…

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Enhanced UGT1A1 Gene and Protein Expression in Endometriotic Lesions.

Enhanced UGT1A1 Gene and Protein Expression in Endometriotic Lesions. By Dr. Youngran Park

The estrogen plays an essential role in endometriosis. Lately, it is becoming evident that, besides the circulating levels of estrogens, the balance of synthesis versus inactivation (metabolism) of estrogens by intralesional steroid-metabolizing enzymes also determines the local net estrogen availability.…

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Endometriosis : A Whole Body Disease

Endometriosis : A Whole Body Disease By Kasthuri Nair

Endometriosis is a disease that impacts multiple parts of an individual’s body. Seminars in Reproductive Medicine recently published a paper by Alderman III et al. entitled “The Systemic Effects of Endometriosis” explores the various comorbidities that can affect individuals suffering…

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