A Key Modulator of Natural Killer Cell Dysfunction in Endometriosis: Soluble MICA

A Key Modulator of Natural Killer Cell Dysfunction in Endometriosis: Soluble MICA By Hakan Kula

In a study published in the American Journal of the Reproductive Immunology, Abrao et al. investigated the potential effect of MHC Class I related MICA molecules at the pathogenesis of the endometriosis.  This study highlights a novel role of soluble MICA (sMICA) in endometriosis, showing…

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Activities of cytotoxic cells in endometriosis

Activities of cytotoxic cells in endometriosis By Eylül GÜN

Immunological dysfunction is thought to be involved in the etiopathogenesis of endometriosis, leading to defective immunosurveillance and the growth of endometriotic lesions. In this pathway, reduced cytotoxicity of peripheral and peritoneal natural killer (NK) cells is seen as a contributing…

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Enhanced local and systemic inflammatory cytokine mRNA expression in women with endometriosis 

Enhanced local and systemic inflammatory cytokine mRNA expression in women with endometriosis  By Ellen Tumimbang

Endometriosis is not only characterized by the implantation of endometriotic tissue outside of the uterine cavity but also necessitates an impaired immune response. It is suggested that abnormal immunological mechanisms causing the dysfunction of immune cells and their mediators are…

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Therapeutic potential of ginseng based compound in preclinical models of endometriosis

Therapeutic potential of ginseng based compound in preclinical models of endometriosis By Yu Yu

Currently, the drug option for women with endometriosis mainly focus on reducing estrogens levels (e.g., progestins, androgens, gonadotropin-releasing hormone (GnRH) agonists, and aromatase inhibitors). However, these therapies can have low effectiveness with frequent recurrence and considerable side effects. Therefore, there…

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The Role of Natural Killer Cells in the Development of Endometriosis Unravelled

The Role of Natural Killer Cells in the Development of Endometriosis Unravelled By Özge Özkaya

Specialized immune cells called natural killer cells found in the peritoneal fluid of women with severe endometriosis may facilitate the development of the disease, according to a study published in the American Journal of Reproductive Immunology.   This finding could help…

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