Cervix as a Missing Link in Endometriosis Pathogenesis
The cervix, a 4 cm-long, 2.5–3 cm-wide segment at the lower end of the uterus, plays multiple roles in women’s reproductive health. Lined with mucus rich in antimicrobial peptides, immunoglobulins, immune cells, and exfoliated epithelial cells, it acts as both…
Key Points Lay SummaryIntrinsic Potential Factors in Retrograde Menstruation
The mechanistic model of endometriosis pathogenesis suggests that anatomical factors promoting retrograde menstruation are crucial and biologically sound. This model is supported by the strong link between obstructive Müllerian anomalies and endometriosis, indicating a causal relationship between the amount of…
Key Points Lay SummaryDoes the presence of endometriosis increase the risk of gynecologic malignancies?
Endometriosis shares common risk factors with endometrial carcinoma and ovarian carcinomas such as obesity, type 2 diabetes, hyperestrogenism, and reproductive characteristics. Endometriosis is also known to be a risk factor for gynecologic malignant tumors. In this study, Li et.al. have…
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