Does T-cadherin have a role in endometriosis?


Does T-cadherin have a role in endometriosis?

A novel research on with potential theraupetic implications: T-cadherin in endometriosis

Key Points

Importance:

  • There is currently no valid biomarker for endometriosis. 
  • A molecule named "T-cadherin" controlling migration and invasion in different cancers, has not been explored in endometriosis yet.

Highlights:

  • Downregulation of T-cadherin, a molecule from the cadherin family, is related to the invasion and metastasis of malignant tumors.
  • Data in this research provide new insights into the pathogenesis of endometriosis, and most importantly T-cadherin may be a new potential therapeutic target in endometriosis.

What's done here:

  • The expression of T-cadherin(n=40) with and without endometriosis (n= 24) was investigated.
  • Invasion, migration and signaling pathway regulation of T-cadherin overexpression were also studied on isolated endometrial stromal cells.

Key results: 

Lay Summary

Qinsheng Lu and associates from Guangzhou Medical University, China made a unique study of T-cadherin expression in endometriosis and published their results in the journal "Human Reproduction". 

Endometriosis is a common condition of reproductive age women, where hormones, immunity, environment and genetic/epigenetic gene alterations play a role in the pathogenesis.

Though endometriosis is not a malignant disease endometriotic tissues have many cancer-like features, such as cell invasion, migration, proliferation, and anti-apoptosis. T-cadherin expression is reduced in various types of cancers, including bladder cancer, lymphoma, prostate cancer, and oral squamous cell carcinomas.

Here, the expression status of T-cadherin in endometriosis and the effects of T-cadherin on migration and invasion of endometrial stromal cells were investigated. The expression status of T-cadherin in 40 patients with and 24 without endometriosis were analyzed. Besides, invasion, migration and signaling pathway regulation of T-cadherin overexpression were studied on isolated endometrial stromal cells.

The expression of T-cadherin was examined by immunohistochemistry staining and western blot. H-score was used to evaluate the staining intensity of T-cadherin. The correlation between T-cadherin expression levels and endometriosis patients’ age, stage, lesion size, and adhesion were analyzed. Endometrial stromal cells were also isolated and cell invasion, migration was detected by transwell assays after T-cadherin overexpression. The expression of vimentin in T-cadherin-overexpressed cells was detected by western blot.

In the current research, there was no difference in the expression of T-cadherin between eutopic endometrium from endometriosis patients versus controls. However, T-cadherin was significantly downregulated in the ectopic endometrium of endometriotic patients, compared with others. T-cadherin is a tumor suppressor in malignancies, so the downregulation of T-cadherin in endometriotic ectopic lesions may play a role in the pathogenesis of endometriosis.

These data presented here provide new insights into the pathogenesis of endometriosis, and T-cadherin may be a new potential therapeutic target also. However, detailed effects and mechanisms of T-cadherin in endometriosis needs to be further studied .

 


Research Source: https://www.ncbi.nlm.nih.gov/pubmed/31886853


DISCLAIMER

EndoNews highlights the latest peer-reviewed scientific research and medical literature that focuses on endometriosis. We are unbiased in our summaries of recently-published endometriosis research. EndoNews does not provide medical advice or opinions on the best form of treatment. We highly stress the importance of not using EndoNews as a substitute for seeking an experienced physician.