A new hope for a "targeted" drug for endometriosis

A new hope for a By Selma Oransay

Lin et al. from National Cheng Kung University, Taiwan, recently published in"Theranostics" the article entitled "Targeting Anthrax Toxin Receptor 2 Ameliorates Endometriosis Progression”,  report that ANTRX2 may be a novel therapeutic target for endometriosis. Thinking that the adhesion should be the first and the…

Key Points Lay Summary

The role of adhesion molecules, E-cadherin and hScrib, in endometriosis

The role of adhesion molecules, E-cadherin and hScrib, in endometriosis By Engin Aydin

Dr. Zhuo Ouyang and associates from the Capital Medical University, Beijing, China have recently published their research related to adhesion molecules in "Medicine (Baltimore)". Endometriosis is a “benign gynecological disease with some similarities to cancer”. Adhesion molecules E-cadherin and hScrib…

Key Points Lay Summary

Conservative Surgery May Be Sufficient to Halt the Development of Deep Endometriosis

Conservative Surgery May Be Sufficient to Halt the Development of Deep Endometriosis By Özge Özkaya

Deep endometriosis develops as a result of collective cell migration and nerve recruitment from surrounding organs, suggests a study published in the scientific journal Fertility and Sterility.   Collective cell migration is the biological process whereby a group of cells moves…

Key Points Lay Summary

Adhesion molecules and endometriosis

Adhesion molecules and endometriosis By Yu Yu

Decoy receptor 3 (DcR3) is an immunomodulator regulated by estrogen and can regulate cell adhesion, which is a critical step in the initiation of endometriosis. In particular, the cell adhesion molecules, including ICAM-1 (intercellular adhesion molecule 1) and HCAM (homing…

Key Points Lay Summary

TGF-β1 Increases Cell Adhesion and Drives Disease Progression

TGF-β1 Increases Cell Adhesion and Drives Disease Progression By Kasthuri Nair

Without a doubt, the mechanism that drives endometriosis disease progression is complicated. Choi et al. look to elucidate one part of this complex process. They seek to understand the role of transforming growth factor β1 (TGF-β1) in the initial adhesion…

Key Points Lay Summary